Step : 2 Simple reference to JavaScript is not adequate, we need
to bridge this script to server runtime phase using ScriptManager in
Ajax Extension

Default.aspx.
<%@ Page Language="C#" AutoEventWireup="true" CodeFile="Default.aspx.cs"
Inherits="_Default" %>
<!DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN"
"http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd">
<html xmlns="http://www.w3.org/1999/xhtml">
<head runat="server">
<title>mm.SimpleScriptManager1 : </title>
</head>
<body>
<form id="form1" runat="server">
<div> <asp:Button ID="Button1" runat="server" Text="Page-Load()"
onclick="Button1_Click" />    
<asp:ScriptManager ID="ScriptManager1" runat="server">
<Scripts> <asp:ScriptReference Path="~/simple.js" /></Scripts> </asp:ScriptManager>
<a onclick="javascript:do_something();"> Click Me: A Script
Function</a><br />
<span id="TaskMessage" runat="server">
</span>
<span id="Span1" runat="server">
</span>
</div>
</form>
</body>
</html>
Default.aspx.cs
using System;
using System.Collections.Generic;
using System.Linq;
using System.Web;
using System.Web.UI;
using System.Web.UI.WebControls;
using System.Data;
public partial class _Default : System.Web.UI.Page
{
private static int n1;
protected void Page_Load(object sender, EventArgs e)
{
TaskMessage.InnerHtml ="Page Loaded" + Convert.ToString(n1++) +
"Times" ;
}
protected void Button1_Click(object sender, EventArgs e)
{
// just to fire page load
}
}